GenePage for the arcZ gene of Escherichia coli K-12

Primary Gene Name: arcZ
EcoGene Accession Number: EG31163
K-12 Gene Accession Number: ECK3199
MG1655 Gene Identifier: b4450
Gene Name Mnemonic: arc-associated sRNA Z
Alternate Gene Symbols: psrA16; ryhA; sraH
Description: sRNA positive antisense regulator of rpoS; binds Hfq
  # bp Upstream # bp Downstream
MW: 38937.09 ---------121 nt Pre-Run BlastN
Left End: 3350577
Left Intergenic Region

Name: elbB_arcZ

Length: 117 bp gap

Orientation: Divergent

Left_end: 3350460

Right_end: 3350576

Centisome: 72.18

Genomic Address
Clockwise
Minute or Centisome (%) = 72.19
Right End: 3350697
Right Intergenic Region

Name: arcZ_arcB

Length: 9 bp overlap

Orientation: Convergent

Left_end: 3350689

Right_end: 3350697

Centisome: 72.19

ArcZ is processed to a 55 nt mature active form (3' fragment) that binds Hfq and rpoS mRNA and positively regulates rpoS translation; an 88 nt 5' ArcZ fragment also accumulates in low amounts (Soper, 2010; Mandin, 2010). The function of arcZ was originally characterized in Salmonella and the tpx and sdaA targets (also regulated by ArcA) have not been verified in E. coli (Papenfort, 2009). Although the precursor RNA can be seen in low amounts, the predominant form of ArcZ is a processed 3' fragment of ~50 nt that accumulates in stationary phase cells (Argaman, 2001). In Salmonella, ArcZ processing is rne-dependent and the ~50 nt mature ArcZ can suppress tpx and sdaC (Papenfort, 2009).

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BamHI EcoRI HindIII