GenePage for the glmY gene of Escherichia coli K-12

Primary Gene Name: glmY
EcoGene Accession Number: EG31155
K-12 Gene Accession Number: ECK2554
MG1655 Gene Identifier: b4441
Gene Name Mnemonic: Glucosamine
Alternate Gene Symbols: sroF; tke1
Description: sRNA activator of glmS mRNA, glmZ processing antagonist
  # bp Upstream # bp Downstream
MW: 59110.32 ---------184 nt Pre-Run BlastN
Left End: 2691157
Left Intergenic Region

Name: glrK_glmY

Length: 58 bp gap

Orientation: Codirectional-

Left_end: 2691099

Right_end: 2691156

Centisome: 57.98

Genomic Address
Counterclockwise
Minute or Centisome (%) = 57.98
Right End: 2691340
Right Intergenic Region

Name: glmY_purL

Length: 315 bp gap

Orientation: Codirectional-

Left_end: 2691341

Right_end: 2691655

Centisome: 57.98

YhbJ(RapZ) is an adaptor protein that recruits GlmZ to the catalytic domain of RNase E; GlmY is an anti-adaptor decoy sRNA that binds YhbJ(RapZ) competitively with GlmZ, protecting it from degradation (Göpel, 2013). GlmY facilitates a cleavage of the glmUS mRNA, upregulating GlmS synthesis, by antagonizing the probable YhbJ(RapZ)-dependent decay of the GlmZ antisense cleavage activator (Urban, 2008; Reichenbach, 2008). Increased GlmZ-Hfq leads to the cleavage of the glmUS mRNA at the glmU stop codon, upregulating GlmS synthesis; YhbJ(RapZ) negatively regulates glmZ (Kalamorz, 2007). A short form 148 nt GlmY(SroF) sRNA has 37 nt processed off the 3' end; the smaller GlmY predominates in rich medium, both are present in minimal medium (Vogel, 2003). RpoN regulon.

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BamHI EcoRI HindIII