GenePage for the sdsR gene of Escherichia coli K-12

Primary Gene Name: sdsR
EcoGene Accession Number: EG31147
K-12 Gene Accession Number: ECK1839
MG1655 Gene Identifier: b4433
Gene Name Mnemonic: Sigma S-dependent sRNA
Alternate Gene Symbols: ryeB; tpke79
Description: Stationary phase sRNA, mutS regulator
  # bp Upstream # bp Downstream
MW: 38871.17 ---------121 nt Pre-Run BlastN
Left End: 1923164
Left Intergenic Region

Name: ryeA_sdsR

Length: 151 bp overlap

Orientation: Convergent

Left_end: 1923164

Right_end: 1923314

Centisome: 41.43

Genomic Address
Counterclockwise
Minute or Centisome (%) = 41.43
Right End: 1923284
Right Intergenic Region

Name: sdsR_yebY

Length: 80 bp gap

Orientation: Codirectional-

Left_end: 1923285

Right_end: 1923364

Centisome: 41.44

The sdsR(ryeB) sRNA negatively regulates mutS mRNA stability, revealing a probably RpoS-dependent mechanism of ampicillin-induced mutagenesis (Gutierrez, 2013). sdsR(ryeB) was initially characterized in Salmonella as a regulator of ompD and named sdsR; E. coli does not have ompD; although sdsR is abundant in stationary phase in E. coli and is probably regulated by RpoS, the RpoS-dependence of sdsR(ryeB) has not yet been shown in E. coli (Fröhlich, 2012).

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BamHI EcoRI HindIII