GenePage for the hda gene of Escherichia coli K-12

Primary Gene Name: hda
EcoGene Accession Number: EG14201
K-12 Gene Accession Number: ECK2492
MG1655 Gene Identifier: b2496
Gene Name Mnemonic: Homolog of dnaA
Alternate Gene Symbols: idaB; yfgE
Description: Required for regulatory inactivation of DnaA; multicopy suppressor of dnaN(ts)
  # bp Upstream # bp Downstream
Verified Start MW: 26632.70 ---------233 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 2618075
Left Intergenic Region

Name: yfgD_hda

Length: 137 bp gap

Orientation: Convergent

Left_end: 2617938

Right_end: 2618074

Centisome: 56.40

Genomic Address
Counterclockwise
Minute or Centisome (%) = 56.40
Right End: 2618776
Right Intergenic Region

Name: hda_uraA

Length: 94 bp gap

Orientation: Codirectional-

Left_end: 2618777

Right_end: 2618870

Centisome: 56.42

hda is a dnaA paralog. The interaction of Hda with DNA polymerase III (beta) is mediated via the hexapeptide sequence and it is this interaction that may lead to events that result in DnaA inactivation. Hda-ADP is the monomeric active form for promoting clamp-mediated DNA-ATP hydrolysis (Su'etsugu, 2008). Hda has a verified CTG start codon (Su'etsugu, 2008). otherPDB (S. amazonensis): 3BOS.

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BamHI EcoRI HindIII