GenePage for the dtpA gene of Escherichia coli K-12

Primary Gene Name: dtpA
EcoGene Accession Number: EG13939
K-12 Gene Accession Number: ECK1630
MG1655 Gene Identifier: b1634
Gene Name Mnemonic: Tripeptide permease
Alternate Gene Symbols: tppB; ydgR
Description: Dipeptide and tripeptide permease A
  # bp Upstream # bp Downstream
MW: 53991.14 ---------500 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 1712769
Left Intergenic Region

Name: nth_dtpA

Length: 610 bp gap

Orientation: Codirectional+

Left_end: 1712159

Right_end: 1712768

Centisome: 36.89

Genomic Address
Clockwise
Minute or Centisome (%) = 36.90
Right End: 1714271
Right Intergenic Region

Name: dtpA_gstA

Length: 105 bp gap

Orientation: Codirectional+

Left_end: 1714272

Right_end: 1714376

Centisome: 36.93

Overexpression increases di- and tri-peptide transport and confers hypersensitivity to alafosfalin (Weitz, 2006). DtpA(TppB) was originally characterized in S. typhimurium. OmpR regulon. dtpA(tppB) is weakly stimulated by anaerobiosis in E. coli; Salmonella dtpA(tppB) is strongly stimulated by anaerobiosis. dtpA(tppB) in both species is not regulated by osmolarity. Salmonella dtpA(tppA) regulatory mutations were shown to be ompR mutations. Salmonella dtpA(tppB) mutants are resistant to the tripeptide antibiotic alafosfalin and cannot satisfy a leucine requirement with trileucine (Gibson, 1984). Major Facilitator Superfamily (MFS).

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BamHI EcoRI HindIII