GenePage for the efeU' pseudogene of Escherichia coli K-12

Primary Gene Name: efeU'
EcoGene Accession Number: EG13860
K-12 Gene Accession Number: ECK1007
MG1655 Gene Identifier: b4490, b1017, b1016
Gene Name Mnemonic: Elemental FErrous iron Uptake
Alternate Gene Symbols: ycdN
Description: Pseudogene reconstruction, ferrous iron permease; intact gene involved in iron uptake
  # bp Upstream # bp Downstream
MW: 30286.90 ---------276 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 1081356
Left Intergenic Region

Name: putP_efeU

Length: 542 bp gap

Orientation: Codirectional+

Left_end: 1080814

Right_end: 1081355

Centisome: 23.29

Genomic Address join

The following join statement uses GenBank syntax to describe how the reconstructed frameshifted efeU pseudogene protein sequence was translated from the DNA:

join(1081356..1081460,1081460..1082185)


Clockwise
Minute or Centisome (%) = 23.30
Right End: 1082185
Right Intergenic Region

Name: efeU_efeO

Length: 57 bp gap

Orientation: Codirectional+

Left_end: 1082186

Right_end: 1082242

Centisome: 23.31

The EfeUOB tripartite iron transporter is silent in E. coli k-12 due to a mutation in EfeU (Cao, 2007). A frameshift at position 36 was conceptually repaired, using the wildtype allele from Shigella sonnei Ss046 as a guide, the frameshifted codon (conceptually translated as X) probably encoded a Gly residue. An intact EfeU from E. coli strain Nissle 1917 was functionally characterized as an iron transporter in vivo and in vitro; efeUOB of K-12 are transcribed as an iron-depletion-inducible, Fur-dependent operon (McHugh, 2003; Grosse, 2006). FTR1 iron transporter family. CpxAR-regulon.

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BamHI EcoRI HindIII