GenePage for the gfcC gene of Escherichia coli K-12

Primary Gene Name: gfcC
EcoGene Accession Number: EG13730
K-12 Gene Accession Number: ECK0976
MG1655 Gene Identifier: b0985
Gene Name Mnemonic: Group 4 Capsule
Alternate Gene Symbols: ymcB
Description: Predicted periplasmic protein; required to make O-antigen capsule
  # bp Upstream # bp Downstream
MW: 27296.13 ---------248 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 1047945
Left Intergenic Region

Name: gfcD_gfcC

Length: 1 bp overlap

Orientation: Codirectional-

Left_end: 1047945

Right_end: 1047945

Centisome: 22.58

Genomic Address
Counterclockwise
Minute or Centisome (%) = 22.58
Right End: 1048691
Right Intergenic Region

Name: gfcC_gfcB

Length: 4 bp overlap

Orientation: Codirectional-

Left_end: 1048688

Right_end: 1048691

Centisome: 22.59

E. coli K-12 does not produce O-antigen capsule polysaccharide because the cryptic gfcABCDE-etp-etk operon is silenced by IS1D in the promoter region (Peleg, 2005). GfcC is required for O-antigen capsule formation in enteropathogenic E. coli (EPEC) (Peleg, 2005). yjbG and gfcC(ymcB) are paralogs. The first 22 aa of GfcC are predicted to be a type I signal peptide. Although the crystal structure of E. coli GfcC is from strain O127:H6, it has only four mismatches as compared to the K-12 GfcC (Sathiyamoorthy, 2011).

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BamHI EcoRI HindIII