GenePage for the hspQ gene of Escherichia coli K-12

Primary Gene Name: hspQ
EcoGene Accession Number: EG13724
K-12 Gene Accession Number: ECK0957
MG1655 Gene Identifier: b0966
Gene Name Mnemonic: Heat Shock Protein
Alternate Gene Symbols: yccV
Description: Heat shock protein involved in degradation of mutant DnaA; hemimethylated oriC DNA-binding protein; mutation suppresses some dnaA(Ts)
  # bp Upstream # bp Downstream
Verified Start MW: 11779.20 ---------105 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 1028404
Left Intergenic Region

Name: yccU_hspQ

Length: 44 bp gap

Orientation: Convergent

Left_end: 1028360

Right_end: 1028403

Centisome: 22.16

Genomic Address
Counterclockwise
Minute or Centisome (%) = 22.16
Right End: 1028721
Right Intergenic Region

Name: hspQ_rlmI

Length: 57 bp gap

Orientation: Codirectional-

Left_end: 1028722

Right_end: 1028778

Centisome: 22.16

A mutation in hspQ allows some dnaA(Ts) strains to grow at 40C, and slows the degradation of DnaA508 at 40C. Despite forcing translation at the upstream start, some HspQ(YccV) protein likely initiating at this true start site was observed by d'Alencon et al. (2003). Binding to hemimethylated oriC is specific, but weak, possibly due to the extra 17 N-terminal residues on the purified HspQ(YccV). RpoH regulon.

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BamHI EcoRI HindIII