GenePage for the ecpA gene of Escherichia coli K-12

Primary Gene Name: ecpA
EcoGene Accession Number: EG13565
K-12 Gene Accession Number: ECK0292
MG1655 Gene Identifier: b0293
Gene Name Mnemonic: E. coli common pilus
Alternate Gene Symbols: matB; yagZ
Description: ECP pilin
  # bp Upstream # bp Downstream
Verified Start MW: 20111.47 ---------195 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 310084
Left Intergenic Region

Name: ecpB_ecpA

Length: 57 bp gap

Orientation: Codirectional-

Left_end: 310027

Right_end: 310083

Centisome: 6.68

Genomic Address
Counterclockwise
Minute or Centisome (%) = 6.68
Right End: 310671
Right Intergenic Region

Name: ecpA_ecpR

Length: 74 bp gap

Orientation: Codirectional-

Left_end: 310672

Right_end: 310745

Centisome: 6.69

The O18ac:K1:H7 NMEC ecpRAB(matABC) genes are required for E. coli common pilus (Mat fimbria) formation when cloned in K-12; (Pouttu, 2001).The E. coli O18ac:K1:H7 NMEC ecpABCDE(matBCDEF) genes are all individually required for E. coli common pilus (ECP) formation in the pathogenic E.coli NMEC strains and ECP production enhances low-temperature biofilm formation in NMEC and and also in K-12 when the silent ecp operon is expressed; ecpR(matA) mRNA was detected in K-12, but not ecpAB(matBC) mRNA (Pouttu, 2001; Lehti, 2010; Garnett, 2012). The EcpA(MatB) crystal structure is from strain CFT073 and differs from the K-12 sequence at two positions (Garnett, 2012). EcpA is subject to SecB-dependent cleavage (Marani, 2006).

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BamHI EcoRI HindIII