GenePage for the csgE gene of Escherichia coli K-12

Primary Gene Name: csgE
EcoGene Accession Number: EG13411
K-12 Gene Accession Number: ECK1025
MG1655 Gene Identifier: b1039
Gene Name Mnemonic: Curlin sigma S-dependent growth
Alternate Gene Symbols: agfE(S.t.)
Description: Curlin secretion specificity factor; blocks CsgA amyloid formation; CsgEFG curlin secretion complex
  # bp Upstream # bp Downstream
MW: 14878.81 ---------129 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 1102152
Left Intergenic Region

Name: csgF_csgE

Length: 24 bp gap

Orientation: Codirectional-

Left_end: 1102128

Right_end: 1102151

Centisome: 23.74

Genomic Address
Counterclockwise
Minute or Centisome (%) = 23.74
Right End: 1102541
Right Intergenic Region

Name: csgE_csgD

Length: 4 bp gap

Orientation: Codirectional-

Left_end: 1102542

Right_end: 1102545

Centisome: 23.75

CsgG alone can form outer membrane pores when over-expressed that lack specificity and directionality, leaking out small periplasmic proteins and making cells sensitive (permeable) to external erythromycin; co-expresssion of CsgE with CsgG produces curlin-specific export channels that require a 22 amino acid OM secretion signal from CsgA or, presuambly, CsgB for secretion; CsgE binds to and prevents the premature subunit assembly of curlin CsgA into amyloid fibers (Neninger, 2011). Periplasmic protein with predicted 22 aa signal.

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BamHI EcoRI HindIII