GenePage for the zapA gene of Escherichia coli K-12

Primary Gene Name: zapA
EcoGene Accession Number: EG12878
K-12 Gene Accession Number: ECK2905
MG1655 Gene Identifier: b2910
Gene Name Mnemonic: Z-ring-associated protein
Alternate Gene Symbols: ygfE
Description: FtsZ stabilizer, coiled-coil protein
  # bp Upstream # bp Downstream
MW: 12594.17 ---------109 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 3055612
Left Intergenic Region

Name: ygfB_zapA

Length: 167 bp gap

Orientation: Divergent

Left_end: 3055445

Right_end: 3055611

Centisome: 65.83

Genomic Address
Clockwise
Minute or Centisome (%) = 65.83
Right End: 3055941
Right Intergenic Region

Name: zapA_ssrS

Length: 41 bp gap

Orientation: Codirectional+

Left_end: 3055942

Right_end: 3055982

Centisome: 65.84

ZapA binding promotes FtsZ polymer bundling and inhibits the GTPase activity of FtsZ (Small, 2007). Overexpression causes filamentous biofilm formation. Divisome protein, non-essential. FtsN has been shown by FRET to directly interact with itself, FtsW, FtsI and ZapA (Alexeeva, 2010). ZapA has been shown by FRET to directly interact with itself, FtsN, FtsZ and FtsI (Alexeeva, 2010). 5/23 ZapA(YgfE) peptide masses from MS analysis confirm this start codon and indicate that the initial Met is removed (Maillet, 2007).

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BamHI EcoRI HindIII