GenePage for the yrdD gene of Escherichia coli K-12

Primary Gene Name: yrdD
EcoGene Accession Number: EG12841
K-12 Gene Accession Number: ECK3270
MG1655 Gene Identifier: b3283
Gene Name Mnemonic: Systematic nomenclature
Alternate Gene Symbols: None
Description: ssDNA-binding protein, function unknown; zinc finger domain protein
  # bp Upstream # bp Downstream
MW: 19870.96 ---------180 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 3431420
Left Intergenic Region

Name: tsaC_yrdD

Length: 4 bp gap

Orientation: Codirectional-

Left_end: 3431416

Right_end: 3431419

Centisome: 73.93

Genomic Address
Counterclockwise
Minute or Centisome (%) = 73.93
Right End: 3431962
Right Intergenic Region

Name: yrdD_smg

Length: 28 bp gap

Orientation: Codirectional-

Left_end: 3431963

Right_end: 3431990

Centisome: 73.94

Zinc-bound YrdD binds ssDNA and protects it from DNase I digestion; iron-bound YrdB does not bind ssDNA (Cheng, 2014). An insertion in yrdD suppresses the severe growth defect of a rdgB recA double mutant, indicating that YrdD might be involved in the removal of non-canonical DNA precursors (Budke, 2010). YrdD has three copies of a DNA-binding zinc finger motif (PF01396) also found in the C-terminal domain of topoisomerase I (Tse-Dinh, 1988; Ahumada, 1998; Finn, 2013).

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BamHI EcoRI HindIII