GenePage for the flgM gene of Escherichia coli K-12

Primary Gene Name: flgM
EcoGene Accession Number: EG12664
K-12 Gene Accession Number: ECK1056
MG1655 Gene Identifier: b1071
Gene Name Mnemonic: Flagella
Alternate Gene Symbols: mviS
Description: Anti-sigma 28 (FliA) factor; regulator of FlhD
  # bp Upstream # bp Downstream
MW: 10340.59 ---------97 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 1129835
Left Intergenic Region

Name: flgN_flgM

Length: 4 bp gap

Orientation: Codirectional-

Left_end: 1129831

Right_end: 1129834

Centisome: 24.34

Genomic Address
Counterclockwise
Minute or Centisome (%) = 24.34
Right End: 1130128
Right Intergenic Region

Name: flgM_flgA

Length: 75 bp gap

Orientation: Codirectional-

Left_end: 1130129

Right_end: 1130203

Centisome: 24.35

Flk prevents premature FlgM secretion. FlgM function is stopped when it is secreted into the periplasm or the medum. FlgM is characterized primarily in Salmonella; the fMet of Salmonella FlgM is clipped. yceN was identified as one of two ORFs adjacent to the flg locus in a region originally named mviS, then renamed mviN and mviM when sequenced; mviMN was thought to be required for mouse virulence in Salmonella, but the mviMN deletion in ST39 also removed flgM (Carsiotis, 1989). flgM was later shown to be able to complement the mviS phenotype, and thus flgM is the real mouse virulence gene mviS in this region of the Salmonella chromosome (Schmitt, 1994).

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BamHI EcoRI HindIII