GenePage for the envC gene of Escherichia coli K-12

Primary Gene Name: envC
EcoGene Accession Number: EG12297
K-12 Gene Accession Number: ECK3603
MG1655 Gene Identifier: b3613
Gene Name Mnemonic: Envelope
Alternate Gene Symbols: slm11; yibP
Description: Activator of AmiB,C murein hydrolases, septal ring factor
  # bp Upstream # bp Downstream
MW: 46594.65 ---------419 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 3786838
Left Intergenic Region

Name: gpmM_envC

Length: 33 bp gap

Orientation: Codirectional+

Left_end: 3786805

Right_end: 3786837

Centisome: 81.58

Genomic Address
Clockwise
Minute or Centisome (%) = 81.58
Right End: 3788097
Right Intergenic Region

Name: envC_yibQ

Length: 3 bp gap

Orientation: Codirectional+

Left_end: 3788098

Right_end: 3788100

Centisome: 81.61

NlpD, YgeR, MepM(YebA) and EnvC have C-terminal LytM domains; mutating all four LytM domain genes produces a strain with a severe filamentous phenotype, similar to an amiABC triple mutant, of over 20 times the normal cell length and more than 70 times the normal amount of septa/cell, from 0.5 to 36 septa/cell; also similar to the amiABC mutant, the nlpD-envC-mepM(yebA)-ygeR mutant has altered morphology and delayed onset of lysis after beta-lactam antibiotic treatment (Uehara, 2009). envC is a synthetic lethal with minCDE (Bernhardt, 2004). EnvC is recruited to the septal ring (Bernhardt, 2004; Uehara, 2009). EnvC is needed for FtsZ ring formation at 42C (Ichimura, 2002). EnvC has weak in vitro endoproteolytic activity against beta-casein (Ichimura, 2002). The first 34 aa of EnvC are predicted to be a type I signal peptide. EnvZ is proteolytically processed and localized to the periplasm (Hara, 2000). EnvC apparently had murein hydrolytic activity in an in-gel assay with murein sacculi as substrate, although this is likely to have been due to contamination with AmiC (Bernhardt, 2004; Uehara, 2010). envZ mutants are sensitive to crystal violet. The yibN-envC,gpmM,yibQ divergent operon promoter region binds FNR and envC-gpmM-yibQ expression is activated by FNR (Federowicz, 2014).

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BamHI EcoRI HindIII