GenePage for the ampG gene of Escherichia coli K-12

Primary Gene Name: ampG
EcoGene Accession Number: EG12183
K-12 Gene Accession Number: ECK0427
MG1655 Gene Identifier: b0433
Gene Name Mnemonic: Ampicillin
Alternate Gene Symbols: None
Description: Muropeptide permease, imports GlcNAc-anhMurNAc-peptides; required for cloned Citrobacter freundii AmpR-regulated beta-lactamase induction and murein recycling
  # bp Upstream # bp Downstream
MW: 53245.20 ---------491 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 452070
Left Intergenic Region

Name: cyoA_ampG

Length: 459 bp gap

Orientation: Codirectional-

Left_end: 451611

Right_end: 452069

Centisome: 9.73

Genomic Address
Counterclockwise
Minute or Centisome (%) = 9.74
Right End: 453545
Right Intergenic Region

Name: ampG_yajG

Length: 43 bp gap

Orientation: Codirectional-

Left_end: 453546

Right_end: 453588

Centisome: 9.77

Imported muropeptides must contain the disaccharide GlcNAc-anhMurNAc, which is also efficiently transported without attached peptides. Mutants accumulate GlcNAc-anhMurNAc-tripeptide. Transport inhibited by CCCP. 14 TM helices are [predicted, but fusion studies indicate that predicted hydrophobic helices 5, 6, 11, and 12 are in cytoplasmic loops; AmpG probably has 10 TM helices with N-in, C-in topology. AmpG has been studied using cloned Citrobacter freundii ampR and ampC genes, which are normally on the chromosome of C. freundii. This C. freundii ampC is not the same as the E. coli weak constitutive chromosomal ampC beta-lactamase; E. coli has no ampR gene. Major Facilitator Superfamily (MFS).

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BamHI EcoRI HindIII