GenePage for the gcvA gene of Escherichia coli K-12

Primary Gene Name: gcvA
EcoGene Accession Number: EG11795
K-12 Gene Accession Number: ECK2803
MG1655 Gene Identifier: b2808
Gene Name Mnemonic: Glycine cleavage
Alternate Gene Symbols: None
Description: Transcriptional activator for the gcv operon, glycine-induced
  # bp Upstream # bp Downstream
MW: 34401.54 ---------305 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 2941650
Left Intergenic Region

Name: ygdD_gcvA

Length: 18 bp gap

Orientation: Codirectional-

Left_end: 2941632

Right_end: 2941649

Centisome: 63.37

Genomic Address
Counterclockwise
Minute or Centisome (%) = 63.38
Right End: 2942567
Right Intergenic Region

Name: gcvA_gcvB

Length: 128 bp gap

Orientation: Divergent

Left_end: 2942568

Right_end: 2942695

Centisome: 63.39

GcvA acts as repressor of the glycine cleavage system operon in the absence of glycine, probably antagonized by Crp. The GcvA repressor function is enhanced by exogenous purine addition and requires an interaction with GcvR. Glycine is a co-activator that binds to GcvR and disrupts the GcvA-GcvR interaction.

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BamHI EcoRI HindIII