GenePage for the chrR gene of Escherichia coli K-12

Primary Gene Name: chrR
EcoGene Accession Number: EG11723
K-12 Gene Accession Number: ECK3706
MG1655 Gene Identifier: b3713
Gene Name Mnemonic: Chromate reductase
Alternate Gene Symbols: yieF
Description: Chromate reductase, Class I, flavoprotein; quinone reductase; chromate resistance; reduces mitomycin C; prodrug reducing enzyme
  # bp Upstream # bp Downstream
MW: 20375.56 ---------188 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 3894652
Left Intergenic Region

Name: yieE_chrR

Length: 21 bp gap

Orientation: Codirectional+

Left_end: 3894631

Right_end: 3894651

Centisome: 83.91

Genomic Address
Clockwise
Minute or Centisome (%) = 83.91
Right End: 3895218
Right Intergenic Region

Name: chrR_adeP

Length: 53 bp gap

Orientation: Convergent

Left_end: 3895219

Right_end: 3895271

Centisome: 83.92

YieF was renamed as ChrR and is both a chromate and uranyl reductase; a Y128N mutation improves the metal reduction activity of ChrR making it more useful as a bioremediation agent (Barak, 2006). The physiological role of ChrR may be due to its quinone reductase activity. The chrR(yieF) mutant enzyme Y6 kills HeLa spinner cells. The yieE-chrR operon promoter region binds ArcA and ArcA represses yieE-chrR expression (Federowicz, 2014).

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BamHI EcoRI HindIII