GenePage for the bacA gene of Escherichia coli K-12

Primary Gene Name: bacA
EcoGene Accession Number: EG11665
K-12 Gene Accession Number: ECK3047
MG1655 Gene Identifier: b3057
Gene Name Mnemonic: Bacitracin
Alternate Gene Symbols: uppP
Description: Undecaprenyl pyrophosphate phosphatase; BacA(UppP)
  # bp Upstream # bp Downstream
MW: 29758.76 ---------273 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 3203310
Left Intergenic Region

Name: cca_bacA

Length: 180 bp gap

Orientation: Convergent

Left_end: 3203130

Right_end: 3203309

Centisome: 69.01

Genomic Address
Counterclockwise
Minute or Centisome (%) = 69.01
Right End: 3204131
Right Intergenic Region

Name: bacA_folB

Length: 89 bp gap

Orientation: Codirectional-

Left_end: 3204132

Right_end: 3204220

Centisome: 69.03

Overexpression of bacA confers bacitracin resistance (Cain, 1993). Purified BacA has undecaprenyl pyrophosphate phosphatase (UppP) activity, not the previously hypothesized undecaprenol phosphokinase activity; as bacA was the first of four UppP-encoding genes characterized, it was proposed to be renamed uppP which is retained as a synonym (Cain, 1993; El Ghachi, 2004). BacA(UppP) encodes 75% of the cell's UppP activity; the bacA gene is not essential, but UppP activity is essential to synthesize undecaprenyl phosphate, a C55 lipid carrier for cell wall synthesis, so a ybjG pgpB bacA triple mutant of three UppP-encoding genes is lethal; overexpression, but not wildtype levels, of the LpxT(YeiU) undecaprenyl pyrophosphate:lipid A 1-phosphate phosphotransferase activity rescues the triple mutant (El Ghachi, 2004; El Ghachi, 2005). YbjG and BacA are not involved in lipid A modification (Touze, 2008).

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BamHI EcoRI HindIII