GenePage for the clsA gene of Escherichia coli K-12

Primary Gene Name: clsA
EcoGene Accession Number: EG11608
K-12 Gene Accession Number: ECK1243
MG1655 Gene Identifier: b1249
Gene Name Mnemonic: Cardiolipin synthase
Alternate Gene Symbols: cls; nov; yciJ
Description: Cardiolipin synthase 1; mutants are dihydroxybutylphosphonate resistant; novobiocin sensitivity
  # bp Upstream # bp Downstream
MW: 54822.33 ---------486 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 1307185
Left Intergenic Region

Name: yciU_clsA

Length: 34 bp gap

Orientation: Codirectional-

Left_end: 1307151

Right_end: 1307184

Centisome: 28.16

Genomic Address
Counterclockwise
Minute or Centisome (%) = 28.16
Right End: 1308645
Right Intergenic Region

Name: clsA_yciY

Length: 142 bp gap

Orientation: Divergent

Left_end: 1308646

Right_end: 1308787

Centisome: 28.19

Three paralogous cls genes encoding cardiolipin synthases, clsA(cls), clsB(ybhO) and clsC(ymdC), need to be deleted in order to prevent in vivo cardiolipin synthesis; most studies on the effects of cardiolipin depletion only used clsA(cls) mutant strains that still sythesize cardiolipin (Tan, 2012). Overexpression causes filamentous biofilm formation.

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BamHI EcoRI HindIII