GenePage for the ftsH gene of Escherichia coli K-12

Primary Gene Name: ftsH
EcoGene Accession Number: EG11506
K-12 Gene Accession Number: ECK3167
MG1655 Gene Identifier: b3178
Gene Name Mnemonic: Filamentation, temperature sensitive
Alternate Gene Symbols: hflB; mrsC; std; tolZ
Description: ATP-dependent membrane protease, complexed with HflCK; regulates lysogeny; mutants are defective in cell growth, septum formation and phage lambda development; mutants rescued by divalent cations; binds Zn(II); hexameric
  # bp Upstream # bp Downstream
MW: 70708.09 ---------644 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 3325001
Left Intergenic Region

Name: folP_ftsH

Length: 89 bp gap

Orientation: Codirectional-

Left_end: 3324912

Right_end: 3325000

Centisome: 71.63

Genomic Address
Counterclockwise
Minute or Centisome (%) = 71.63
Right End: 3326935
Right Intergenic Region

Name: ftsH_rlmE

Length: 99 bp gap

Orientation: Codirectional-

Left_end: 3326936

Right_end: 3327034

Centisome: 71.68

HtpX collaborates with FtsH to eliminate abnormal membrane proteins: an hflX ftsH double mutant is temperature sensitive for growth. FtsH degrades both cytoplasmic, e.g. phage lambda cII protein, and membrane, e.g. SecY, substrates.

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BamHI EcoRI HindIII