GenePage for the acnA gene of Escherichia coli K-12

Primary Gene Name: acnA
EcoGene Accession Number: EG11325
K-12 Gene Accession Number: ECK1271
MG1655 Gene Identifier: b1276
Gene Name Mnemonic: Aconitase
Alternate Gene Symbols: acn
Description: Aconitate hydratase 1; aconitase A, stationary phase induced; iron-sulfur cluster
  # bp Upstream # bp Downstream
Verified Start MW: 97677.22 ---------891 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 1335831
Left Intergenic Region

Name: yciX_acnA

Length: 372 bp gap

Orientation: Codirectional+

Left_end: 1335459

Right_end: 1335830

Centisome: 28.77

Genomic Address
Clockwise
Minute or Centisome (%) = 28.78
Right End: 1338506
Right Intergenic Region

Name: acnA_ribA

Length: 63 bp gap

Orientation: Convergent

Left_end: 1338507

Right_end: 1338569

Centisome: 28.84

AcnA is produced in the stationary growth phase, interconverting citrate and iso-citrate via cis-aconitate (Cunningham, 1997). During oxidative stress inactive AcnA apo-enzyme without iron sulphur clusters binds the acnA mRNA 3' UTR, stabilizes acnA mRNA and increases AcnA synthesis, thus mediating a post-transcriptional positive autoregulatory switch (Tang, 1999). acnA is negatively regulated by ryhB RNA as part of indirect positive regulation by Fur in response to iron availability (Masse, 2002).

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BamHI EcoRI HindIII