GenePage for the emrE gene of Escherichia coli K-12

Primary Gene Name: emrE
EcoGene Accession Number: EG10629
K-12 Gene Accession Number: ECK0534
MG1655 Gene Identifier: b0543
Gene Name Mnemonic: Efflux-multidrug resistance
Alternate Gene Symbols: eb; mvrC
Description: Multidrug resistance pump, DLP12 prophage; methylviologen sensitivity
  # bp Upstream # bp Downstream
MW: 11958.37 ---------110 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 568315
Left Intergenic Region

Name: renD_emrE

Length: 67 bp gap

Orientation: Codirectional+

Left_end: 568248

Right_end: 568314

Centisome: 12.24

Genomic Address
Clockwise
Minute or Centisome (%) = 12.24
Right End: 568647
Right Intergenic Region

Name: emrE_ybcK

Length: 254 bp gap

Orientation: Codirectional+

Left_end: 568648

Right_end: 568901

Centisome: 12.25

EmrE defunct PDB structures 1S7B and 2F2M, and any conclusions derived from these structures, have been retracted due to a software data inversion error (Chang, 2006; Ma, 2007). Correct structures are now available. EmrE belongs to the SMR efflux pump family, DMT superfamily. EmrE accomplishes multidrug efflux by coupling conformational changes between two heterodimers with proton gradient. Although the dual-topology membrane protein structure suggested by the original cryo EM studies has been controversial, the emerging consensus from different experimental approaches is that EmrE is an asymmetric dimer with the two monomers in antiparallel orientations in the membrane (Korkhov, 2009).

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BamHI EcoRI HindIII