GenePage for the htpG gene of Escherichia coli K-12

Primary Gene Name: htpG
EcoGene Accession Number: EG10461
K-12 Gene Accession Number: ECK0467
MG1655 Gene Identifier: b0473
Gene Name Mnemonic: High-temperature production
Alternate Gene Symbols: None
Description: Protein refolding molecular co-chaperone Hsp90, Hsp70-dependent; heat-shock protein; ATPase; dimeric
  # bp Upstream # bp Downstream
Verified Start MW: 71422.53 ---------624 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 495120
Left Intergenic Region

Name: recR_htpG

Length: 109 bp gap

Orientation: Codirectional+

Left_end: 495011

Right_end: 495119

Centisome: 10.66

Genomic Address
Clockwise
Minute or Centisome (%) = 10.67
Right End: 496994
Right Intergenic Region

Name: htpG_adk

Length: 180 bp gap

Orientation: Codirectional+

Left_end: 496995

Right_end: 497174

Centisome: 10.71

HtpG(Hsp90) interacts with DnaK(Hsp70) to remodel heat-inactivated luciferase (Genest (2011). HtpG undergoes substantial nucleotide-dependent conformational rearrangements (Huai, 2005; Shiau, 2006). HtpG can form heterodimers with human HSP90alpha. In vitro, HtpG transitions to oligomeric form at 65C, required for substrate solubilization. Binds TrxA (Kumar, 2004). Geldanamycin inhibits HtpG(Hsp90) ATPase activity. HtpG binds RpoH and htpG is in the rpoH regulon.

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BamHI EcoRI HindIII