GenePage for the glpC gene of Escherichia coli K-12

Primary Gene Name: glpC
EcoGene Accession Number: EG10393
K-12 Gene Accession Number: ECK2235
MG1655 Gene Identifier: b2243
Gene Name Mnemonic: Glycerol phosphate
Alternate Gene Symbols: glpB
Description: Anaerobic glycerol-3-phosphate dehydrogenase subunit C; 4Fe-4S iron-sulfur cluster and membrane anchor
  # bp Upstream # bp Downstream
Verified Start MW: 44108.04 ---------396 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 2355521
Left Intergenic Region

Name: glpB_glpC

Length: 4 bp overlap

Orientation: Codirectional+

Left_end: 2355521

Right_end: 2355524

Centisome: 50.75

Genomic Address
Clockwise
Minute or Centisome (%) = 50.75
Right End: 2356711
Right Intergenic Region

Name: glpC_yfaD

Length: 192 bp gap

Orientation: Codirectional+

Left_end: 2356712

Right_end: 2356903

Centisome: 50.77

The GlpC subunit of glycerol-3-phosphate dehydrogenase has an N-terminal 4Fe-4S dicluster domain (pfam PF12838) with 8 conserved Cys residues; GlpC also has two C-terminal cysteine-rich domains (Pfam PF02754) each with invariant CCG motifs and two conserved single Cys residues that may be a membrane anchor. GlpAB is the catalytic dimer and GlpC is the iron-sulfur protein and membrane anchor; the GlpC and GlpB names are sometimes switched. glcF and glpC are homologous horizontal transfer (HT) genes. glpC was also identified as responsiible for increased organic solvent tolerance. HT_Cmplx44_Mem: GlpC+KdgK+YahK.

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BamHI EcoRI HindIII