GenePage for the ftsY gene of Escherichia coli K-12

Primary Gene Name: ftsY
EcoGene Accession Number: EG10346
K-12 Gene Accession Number: ECK3448
MG1655 Gene Identifier: b3464
Gene Name Mnemonic: Filamentation, temperature sensitive
Alternate Gene Symbols: None
Description: Signal recognition particle (SRP) receptor, GTPase
  # bp Upstream # bp Downstream
Verified Start MW: 54513.35 ---------497 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 3602750
Left Intergenic Region

Name: ftsE_ftsY

Length: 2 bp gap

Orientation: Codirectional-

Left_end: 3602748

Right_end: 3602749

Centisome: 77.62

Genomic Address
Counterclockwise
Minute or Centisome (%) = 77.62
Right End: 3604243
Right Intergenic Region

Name: ftsY_rsmD

Length: 149 bp gap

Orientation: Divergent

Left_end: 3604244

Right_end: 3604392

Centisome: 77.65

The Ffh GTPase is stimulated by FtsY and the FtsY GTPase is stimulated by Ffh. FtsY binds ribosomes in a SRP (Ffh+Ffs) particle- and GTP-dependent manner, releasing trigger factor (Tig) from the ribosome (Buskiewicz, 2004). FtsY is found as both membrane-associated isoforms and as shorter soluble isoforms which are lacking the N-terminal 14 aa; FtsY is attached to the cytoplasmic membrane by its association with the secYEG translocon and the FtsY N-terminal 14 aa cleavable membrane anchor facilitates this association by first transiently anchoring FtsY to the membrane (Luirink, 1994; Weiche, 2008). The N-termini of both short and long forms have been verified (Luirink, 1994; Weiche, 2008). OtherPDB (T. aquaticus): 2CNW.

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BamHI EcoRI HindIII