GenePage for the ftsQ gene of Escherichia coli K-12

Primary Gene Name: ftsQ
EcoGene Accession Number: EG10342
K-12 Gene Accession Number: ECK0094
MG1655 Gene Identifier: b0093
Gene Name Mnemonic: Filamentation, temperature sensitive
Alternate Gene Symbols: None
Description: Divisome assembly protein; cell division and growth of wall at septum
  # bp Upstream # bp Downstream
MW: 31433.73 ---------276 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 103155
Left Intergenic Region

Name: ddlB_ftsQ

Length: 1 bp gap

Orientation: Codirectional+

Left_end: 103154

Right_end: 103154

Centisome: 2.22

Genomic Address
Clockwise
Minute or Centisome (%) = 2.22
Right End: 103985
Right Intergenic Region

Name: ftsQ_ftsA

Length: 4 bp overlap

Orientation: Codirectional+

Left_end: 103982

Right_end: 103985

Centisome: 2.24

Overexpression of ftsQ causes filamentous biofilm formation. Although FtsQ co-precipitates with FtsL and FtsB, it does not require the presence of FtsLB for mid-cell localization. FtsQ is a single transmembrane helix inner membrane protein; the 25 N-terminal aa are in cytoplasm; the last 225 aa are in periplasm. FtsQ is an essential gene. FtsQ is localized to septum by its periplasmic domain. FtsQ is targeted by SRP/FtsY to Sec/YidC for membrane insertion. FtsQ is divisome protein. blr is a multi-copy suppressor of ftsQ1(Ts), obviating the need for salt-suppression of ftsQ1; blr mutations exacerbate the ftsQ1(Ts) phenotype (Karimova, 2012).

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BamHI EcoRI HindIII