GenePage for the fis gene of Escherichia coli K-12

Primary Gene Name: fis
EcoGene Accession Number: EG10317
K-12 Gene Accession Number: ECK3248
MG1655 Gene Identifier: b3261
Gene Name Mnemonic: Factor for inversion stimulation
Alternate Gene Symbols: nbp
Description: Transcriptional activator for rRNA operons, bends DNA; interacts with RNAP; nucleoid-associated protein; dimeric
  # bp Upstream # bp Downstream
Verified Start MW: 11239.93 ---------98 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 3411271
Left Intergenic Region

Name: dusB_fis

Length: 25 bp gap

Orientation: Codirectional+

Left_end: 3411246

Right_end: 3411270

Centisome: 73.49

Genomic Address
Clockwise
Minute or Centisome (%) = 73.49
Right End: 3411567
Right Intergenic Region

Name: fis_yhdJ

Length: 85 bp gap

Orientation: Codirectional+

Left_end: 3411568

Right_end: 3411652

Centisome: 73.50

fis transcription is supercoiling-dependent. Overexpression causes filamentous biofilm formation. Decreased levels of Fis inhibit open complex formation, inhibiting oriC unwinding by blocking IHF and DnaA low affinity binding sites. Polyamine modulon (Igarashi, 2006). Mutations in fis affect chromosomal supercoiling.

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BamHI EcoRI HindIII