GenePage for the fecI gene of Escherichia coli K-12

Primary Gene Name: fecI
EcoGene Accession Number: EG10291
K-12 Gene Accession Number: ECK4283
MG1655 Gene Identifier: b4293
Gene Name Mnemonic: Ferric citrate
Alternate Gene Symbols: None
Description: RNA polymerase sigma-19 factor; fecA promoter RNAP sigma factor
  # bp Upstream # bp Downstream
MW: 19480.41 ---------173 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 4517714
Left Intergenic Region

Name: fecR_fecI

Length: 4 bp overlap

Orientation: Codirectional-

Left_end: 4517714

Right_end: 4517717

Centisome: 97.33

Genomic Address
Counterclockwise
Minute or Centisome (%) = 97.33
Right End: 4518235
Right Intergenic Region

Name: fecI_insA6

Length: 291 bp gap

Orientation: Divergent

Left_end: 4518236

Right_end: 4518526

Centisome: 97.34

The cytoplasmic C-terminal domain of FecR is an anti-sigma-19 factor, but sigma-19 (FecI) also requires FecR to function; in the absence of ferric citrate FecI is bound to the membrane by the cytoplasmic domain of the FecR transmembrane signal transducer, which both sequesters FecI and activates or protects FecI; exogenous ferric citrate induces outer membrane transmembrane transducer FecA to signal inner membrane transmembrane transducer FecR to release membrane-bound FecI to bind cytoplasmic core RNA polymerase and activate Fur-dependent fec operon transcription to allow ferric citrate import and relief of iron starvation (Braun, 2006; TreviƱo-Quintanilla, 2013). The Fec iron uptake and transmembrane signaling diferric dicitrate substrate [Fe(3+) citrate]2, is more simply referred to as ferric citrate (Braun, 2005). fecI is part of the polyamine modulon (Igarashi, 2006).

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BamHI EcoRI HindIII