FimA Paralogs


E. coli has 25 FimA homologs encoding pilin subunits. All 25 can be reliably predictd to have signal peptides, but only FimA has been verified by N-terminal sequence. FimA is the major pilin subunit. Homologs include minor pilin variants.


21/25 FimA homologs have between 162 and 194 aa; 4/25 have between 327 and 412 aa and have additional domains. The four long FimA homologs are omitted from the alignment and tree.

The multiple alignment data, the multiple alignment figure, and the neighbor-joining tree data were created using ClustalX locally. The tree figure was drawn using the Phylodendron server at Indiana University.

FimA Multiple Alignment

FimA Paralog Tree