Orthologs

Description:

Orthologs

Details:

Orthologs have one representative each from E. coli K-12 and selected other organisms.

Identifying orthologs is simplified when there is only one clearly "best hit" homolog per organism and when local gene order (microsynteny) is preserved.
Horizontal inheritance or paralogous evolution coupled with with gene loss can be predicted if their positions on ortholog trees deviate signficantly from that expected based on rRNA and other ubiquitous gene ortholog trees.