GenePage for the rhsD gene of Escherichia coli K-12

Primary Gene Name: rhsD
EcoGene Accession Number: EG10849
K-12 Gene Accession Number: ECK0491
MG1655 Gene Identifier: b0497
Gene Name Mnemonic: Recombination hotspot
Alternate Gene Symbols: None
Description: Rhs protein with DUF4329 family putative toxin domain; putative neighboring cell growth inhibitor
  # bp Upstream # bp Downstream
MW: 159724.57 ---------1426 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 523261
Left Intergenic Region

Name: ybbP_rhsD

Length: 430 bp gap

Orientation: Codirectional+

Left_end: 522831

Right_end: 523260

Centisome: 11.26

Genomic Address
Clockwise
Minute or Centisome (%) = 11.27
Right End: 527541
Right Intergenic Region

Name: rhsD_ybbC

Length: 39 bp gap

Orientation: Codirectional+

Left_end: 527542

Right_end: 527580

Centisome: 11.37

It has been suggested that all Rhs systems are involved in intercellular growth inhibition, suggesting that the Rhs proteins are secreted from E. coli and that the variable C-terminal domains are toxic to neighboring cells when secreted to the outside of the cell (Koskiniemi, 2013). rhsD has been predicted to encode a polymorphic toxin and the downstream gene encodes YbbC, a predicted immunity protein (Zhang, 2012).

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BamHI EcoRI HindIII